DNAJB2
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of cell growth [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of inclusion body assembly [IDA]
- negative regulation of protein deubiquitination [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [TAS]
- protein refolding [IDA]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATXN3
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cellular response to heat [ISS]
- cellular response to misfolded protein [ISS]
- intermediate filament cytoskeleton organization [IMP]
- microtubule cytoskeleton organization [IMP]
- misfolded or incompletely synthesized protein catabolic process [ISS]
- monoubiquitinated protein deubiquitination [ISS]
- nervous system development [TAS]
- nucleotide-excision repair [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein K48-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- regulation of cell-substrate adhesion [IMP]
- synaptic transmission [TAS]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3.
Homo sapiens J domain protein (HSJ1) is a J-domain containing co-chaperone that is known to stimulate ATPase activity of HSP70 chaperone, while it also harbors two ubiquitin (Ub)-interacting motifs (UIMs) that may bind with ubiquitinated substrates and potentially function in protein degradation. We studied the effects of HSJ1a on the protein levels of both normal and the disease--related polyQ-expanded forms ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID