BAIT

EHMT2

BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, DAAP-66K18.3
euchromatic histone-lysine N-methyltransferase 2
Homo sapiens
PREY

DNMT3A

DNMT3A2, M.HsaIIIA, TBRS
DNA (cytosine-5-)-methyltransferase 3 alpha
Autism spectrum disorder (ASD) Project
Homo sapiens

Biochemical Activity (Methylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.

Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, Izumi V, Koomen JM, Bedford MT, Zhang X, Shinkai Y, Fang J, Cheng X

DNA CpG methylation and histone H3 lysine 9 (H3K9) methylation are two major repressive epigenetic modifications, and these methylations are positively correlated with one another in chromatin. Here we show that G9a or G9a-like protein (GLP) dimethylate the amino-terminal lysine 44 (K44) of mouse Dnmt3a (equivalent to K47 of human DNMT3A) in vitro and in cells overexpressing G9a or GLP. ... [more]

Nat Commun Nov. 17, 2011; 2(0);533 [Pubmed: 22086334]

Throughput

  • Low Throughput

Additional Notes

  • figure S1.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
EHMT2 DNMT3A
Protein-peptide
Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Low-BioGRID
674200

Curated By

  • BioGRID