RWDD3
Gene Ontology Biological Process
Gene Ontology Molecular Function
HIF1A
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- axon transport of mitochondrion [IMP]
- cellular response to hypoxia [IDA, IEP, TAS]
- cellular response to interleukin-1 [IEP]
- collagen metabolic process [ISS]
- connective tissue replacement involved in inflammatory response wound healing [ISS]
- elastin metabolic process [ISS]
- epithelial to mesenchymal transition [ISS]
- mRNA transcription from RNA polymerase II promoter [IC]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- oxygen homeostasis [IDA]
- positive regulation of angiogenesis [IC]
- positive regulation of chemokine production [TAS]
- positive regulation of chemokine-mediated signaling pathway [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of epithelial cell migration [ISS]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [TAS]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, IMP]
- regulation of gene expression [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- regulation of transcription, DNA-templated [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IDA, IMP]
- signal transduction [IMP]
- vascular endothelial growth factor production [IDA]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.
SUMO conjugation to proteins is involved in the regulation of diverse cellular functions. We have identified a protein, RWD-containing sumoylation enhancer (RSUME), that enhances overall SUMO-1, -2, and -3 conjugation by interacting with the SUMO conjugase Ubc9. RSUME increases noncovalent binding of SUMO-1 to Ubc9 and enhances Ubc9 thioester formation and SUMO polymerization. RSUME enhances the sumoylation of IkB in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RWDD3 HIF1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID