A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation.

Salimova E, Sohrmann M, Fournier N, Simanis V

We have isolated the Schizosaccharomyces pombe orthologue of the Saccharomyces cerevisiae MOB1 gene in a screen designed to enrich for septation mutants. The gene is essential, and cells lacking it display a phenotype typical of septation signalling network mutants. mob1p is located on both spindle pole bodies throughout mitosis. In addition it is also co-localised with the medial ring later ... [more]

J. Cell. Sci. May. 01, 2000; 113(0);1695-704 [Pubmed: 10769201]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

MOB1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein kinase activator activity [IGI]

Gene Ontology Cellular Component

CDC14