GRIN2B
Gene Ontology Biological Process
- action potential [ISO]
- associative learning [ISO]
- behavioral fear response [IMP]
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IMP]
- cation transmembrane transport [IGI]
- cation transport [IGI]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- embryo development [IMP]
- fear response [IMP]
- in utero embryonic development [IMP]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- learning [IDA, IMP]
- learning or memory [TAS]
- memory [IDA, IMP, ISO]
- positive regulation of cell death [ISO]
- positive regulation of glutamate secretion [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [ISO]
- regulation of MAPK cascade [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of neuronal synaptic plasticity [TAS]
- regulation of postsynaptic membrane potential [IMP]
- regulation of protein kinase A signaling [IMP]
- regulation of synaptic plasticity [IMP]
- response to ethanol [IMP, ISO]
- rhythmic process [ISO]
- sensory organ development [IMP]
- startle response [IGI, IMP]
- suckling behavior [IMP]
- synaptic transmission [IMP]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- D2 dopamine receptor binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- beta-catenin binding [ISO]
- calcium channel activity [IMP]
- cation channel activity [IGI]
- cell adhesion molecule binding [ISO]
- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glycine binding [ISO]
- interleukin-1 receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- ionotropic glutamate receptor binding [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- zinc ion binding [ISO]
- D2 dopamine receptor binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- beta-catenin binding [ISO]
- calcium channel activity [IMP]
- cation channel activity [IGI]
- cell adhesion molecule binding [ISO]
- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glycine binding [ISO]
- interleukin-1 receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- ionotropic glutamate receptor binding [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- Z disc [ISO]
- cell surface [IDA]
- dendritic spine [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [ISO]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
N-methyl-d-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength via downstream signaling pathways. We report proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain. The NRC comprised 77 proteins organized into receptor, adaptor, signaling, cytoskeletal and novel proteins, of which 30 are implicated from binding studies and another 19 participate in NMDAR signaling. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SYNGAP1 GRIN2B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SYNGAP1 GRIN2B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343648 | |
| SYNGAP1 GRIN2B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333290 | |
| SYNGAP1 GRIN2B | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.7073 | BioGRID | 3500037 |
Curated By
- BioGRID