GRIN1
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- associative learning [IMP]
- calcium ion homeostasis [IDA]
- calcium ion transmembrane transport [IGI, ISO]
- calcium ion transport [IDA, IMP]
- cation transport [IGI, ISO]
- cellular calcium ion homeostasis [IMP]
- cerebral cortex development [IMP]
- conditioned taste aversion [IMP]
- ion transmembrane transport [IMP]
- ionotropic glutamate receptor signaling pathway [IDA, IGI, ISO]
- learning [IMP]
- learning or memory [IMP]
- long-term memory [IMP]
- male mating behavior [IMP]
- memory [IMP]
- negative regulation of neuron apoptotic process [IGI, IMP]
- neuromuscular process [IMP]
- olfactory learning [IMP]
- pons maturation [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell death [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- prepulse inhibition [IMP]
- propylene metabolic process [IDA]
- protein tetramerization [ISO]
- regulation of axonogenesis [IMP]
- regulation of cell communication [IMP]
- regulation of dendrite morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of ion transmembrane transport [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of neuron apoptotic process [IGI, IMP]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of respiratory gaseous exchange [IMP]
- regulation of synapse assembly [IMP]
- regulation of synaptic plasticity [IMP]
- respiratory gaseous exchange [IMP]
- response to amphetamine [IGI, IMP]
- response to ethanol [ISO]
- response to morphine [IMP]
- rhythmic process [ISO]
- sensory perception of pain [IMP]
- social behavior [IMP]
- startle response [IMP]
- suckling behavior [IMP]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- calcium channel activity [IDA, IGI, ISO]
- calcium ion binding [IDA]
- calmodulin binding [IDA]
- cation channel activity [IGI]
- enzyme binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- glycine binding [IMP, ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- calcium channel activity [IDA, IGI, ISO]
- calcium ion binding [IDA]
- calmodulin binding [IDA]
- cation channel activity [IGI]
- enzyme binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- glycine binding [IMP, ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- cell [IMP]
- cell surface [IDA]
- cytoplasm [IDA]
- dendrite [IDA, ISO]
- dendrite membrane [ISO]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- growth cone [NAS]
- integral component of plasma membrane [ISO]
- membrane [IC, IDA]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- synapse [IDA, ISO]
- synaptic cleft [ISO]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
PTPN11
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- ERBB signaling pathway [ISO]
- abortive mitotic cell cycle [IMP]
- activation of MAPK activity [IMP]
- atrioventricular canal development [ISO]
- axonogenesis [IMP]
- brain development [ISO]
- dephosphorylation [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IGI]
- face morphogenesis [ISO]
- genitalia development [ISO]
- glucose homeostasis [IMP]
- heart development [ISO]
- hormone metabolic process [IMP]
- hormone-mediated signaling pathway [IDA]
- inner ear development [ISO]
- integrin-mediated signaling pathway [IMP]
- lipid metabolic process [IMP]
- megakaryocyte development [IMP]
- multicellular organismal reproductive process [IMP]
- negative regulation of cell adhesion mediated by integrin [IMP]
- negative regulation of cortisol secretion [IMP]
- negative regulation of growth hormone secretion [IMP]
- negative regulation of hormone secretion [IMP]
- negative regulation of insulin secretion [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- organ growth [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- platelet formation [IGI]
- platelet-derived growth factor receptor signaling pathway [IGI]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of signal transduction [IMP, ISO]
- protein dephosphorylation [ISO]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein export from nucleus [IMP]
- triglyceride metabolic process [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
N-methyl-d-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength via downstream signaling pathways. We report proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain. The NRC comprised 77 proteins organized into receptor, adaptor, signaling, cytoskeletal and novel proteins, of which 30 are implicated from binding studies and another 19 participate in NMDAR signaling. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID