BAIT
GRIN2B
AW490526, GluN2B, NR2B, Nmdar2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
GO Process (35)
GO Function (17)
GO Component (14)
Gene Ontology Biological Process
- action potential [ISO]
- associative learning [ISO]
- behavioral fear response [IMP]
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IMP]
- cation transmembrane transport [IGI]
- cation transport [IGI]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- embryo development [IMP]
- fear response [IMP]
- in utero embryonic development [IMP]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- learning [IDA, IMP]
- learning or memory [TAS]
- memory [IDA, IMP, ISO]
- positive regulation of cell death [ISO]
- positive regulation of glutamate secretion [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [ISO]
- regulation of MAPK cascade [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of neuronal synaptic plasticity [TAS]
- regulation of postsynaptic membrane potential [IMP]
- regulation of protein kinase A signaling [IMP]
- regulation of synaptic plasticity [IMP]
- response to ethanol [IMP, ISO]
- rhythmic process [ISO]
- sensory organ development [IMP]
- startle response [IGI, IMP]
- suckling behavior [IMP]
- synaptic transmission [IMP]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- D2 dopamine receptor binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- beta-catenin binding [ISO]
- calcium channel activity [IMP]
- cation channel activity [IGI]
- cell adhesion molecule binding [ISO]
- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glycine binding [ISO]
- interleukin-1 receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- ionotropic glutamate receptor binding [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- zinc ion binding [ISO]
- D2 dopamine receptor binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- beta-catenin binding [ISO]
- calcium channel activity [IMP]
- cation channel activity [IGI]
- cell adhesion molecule binding [ISO]
- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glycine binding [ISO]
- interleukin-1 receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- ionotropic glutamate receptor binding [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- Z disc [ISO]
- cell surface [IDA]
- dendritic spine [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [ISO]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
Mus musculus
PREY
PPP2CA
PP2A, R75353, RP23-46N3.2
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
GO Process (19)
GO Function (15)
GO Component (9)
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- mesoderm development [IMP]
- negative regulation of calcium ion transmembrane transporter activity [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription factor import into nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphatase type 2A activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein dephosphorylation [ISO, TAS]
- protein heterotrimerization [ISO]
- regulation of cell cycle [TAS]
- regulation of protein autophosphorylation [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
N-methyl-d-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength via downstream signaling pathways. We report proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain. The NRC comprised 77 proteins organized into receptor, adaptor, signaling, cytoskeletal and novel proteins, of which 30 are implicated from binding studies and another 19 participate in NMDAR signaling. ... [more]
Nat. Neurosci. Jul. 01, 2000; 3(7);661-9 [Pubmed: 10862698]
Throughput
- Low Throughput
Curated By
- BioGRID