GRIN2B
Gene Ontology Biological Process
- action potential [ISO]
- associative learning [ISO]
- behavioral fear response [IMP]
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IMP]
- cation transmembrane transport [IGI]
- cation transport [IGI]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- embryo development [IMP]
- fear response [IMP]
- in utero embryonic development [IMP]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- learning [IDA, IMP]
- learning or memory [TAS]
- memory [IDA, IMP, ISO]
- positive regulation of cell death [ISO]
- positive regulation of glutamate secretion [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [ISO]
- regulation of MAPK cascade [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of neuronal synaptic plasticity [TAS]
- regulation of postsynaptic membrane potential [IMP]
- regulation of protein kinase A signaling [IMP]
- regulation of synaptic plasticity [IMP]
- response to ethanol [IMP, ISO]
- rhythmic process [ISO]
- sensory organ development [IMP]
- startle response [IGI, IMP]
- suckling behavior [IMP]
- synaptic transmission [IMP]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- D2 dopamine receptor binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- beta-catenin binding [ISO]
- calcium channel activity [IMP]
- cation channel activity [IGI]
- cell adhesion molecule binding [ISO]
- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glycine binding [ISO]
- interleukin-1 receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- ionotropic glutamate receptor binding [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- zinc ion binding [ISO]
- D2 dopamine receptor binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- beta-catenin binding [ISO]
- calcium channel activity [IMP]
- cation channel activity [IGI]
- cell adhesion molecule binding [ISO]
- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glycine binding [ISO]
- interleukin-1 receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- ionotropic glutamate receptor binding [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- Z disc [ISO]
- cell surface [IDA]
- dendritic spine [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [ISO]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
RAC1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IGI]
- GTP catabolic process [IDA, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI]
- actin cytoskeleton organization [ISO]
- actin filament organization [ISO]
- actin filament polymerization [IDA]
- anatomical structure arrangement [IMP]
- auditory receptor cell morphogenesis [IMP]
- axon guidance [IMP]
- bone resorption [ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell motility [ISO]
- cell proliferation [ISO]
- cell-cell junction organization [IMP]
- cellular component movement [ISO]
- cerebral cortex radially oriented cell migration [IMP]
- chemotaxis [ISO]
- cochlea morphogenesis [IMP]
- cytoskeleton organization [IDA]
- dendrite development [IDA]
- dendrite morphogenesis [IGI]
- dopaminergic neuron differentiation [IGI]
- embryonic olfactory bulb interneuron precursor migration [IMP]
- endocytosis [IDA]
- engulfment of apoptotic cell [IDA]
- epithelial cell morphogenesis [IMP]
- hyperosmotic response [IDA]
- lamellipodium assembly [IDA, ISO, TAS]
- localization within membrane [ISO]
- mast cell chemotaxis [ISO]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [IMP, ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [IDA]
- regulation of cell migration [IMP, ISO]
- regulation of respiratory burst [ISO]
- ruffle assembly [IMP]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [ISO]
- small GTPase mediated signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- actin filament [ISO]
- cell projection [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- focal adhesion [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA, ISO]
- phagocytic cup [IDA]
- ruffle membrane [IDA]
- trans-Golgi network [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
N-methyl-d-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength via downstream signaling pathways. We report proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain. The NRC comprised 77 proteins organized into receptor, adaptor, signaling, cytoskeletal and novel proteins, of which 30 are implicated from binding studies and another 19 participate in NMDAR signaling. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID