GRIN1
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- associative learning [IMP]
- calcium ion homeostasis [IDA]
- calcium ion transmembrane transport [IGI, ISO]
- calcium ion transport [IDA, IMP]
- cation transport [IGI, ISO]
- cellular calcium ion homeostasis [IMP]
- cerebral cortex development [IMP]
- conditioned taste aversion [IMP]
- ion transmembrane transport [IMP]
- ionotropic glutamate receptor signaling pathway [IDA, IGI, ISO]
- learning [IMP]
- learning or memory [IMP]
- long-term memory [IMP]
- male mating behavior [IMP]
- memory [IMP]
- negative regulation of neuron apoptotic process [IGI, IMP]
- neuromuscular process [IMP]
- olfactory learning [IMP]
- pons maturation [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell death [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- prepulse inhibition [IMP]
- propylene metabolic process [IDA]
- protein tetramerization [ISO]
- regulation of axonogenesis [IMP]
- regulation of cell communication [IMP]
- regulation of dendrite morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of ion transmembrane transport [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of neuron apoptotic process [IGI, IMP]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of respiratory gaseous exchange [IMP]
- regulation of synapse assembly [IMP]
- regulation of synaptic plasticity [IMP]
- respiratory gaseous exchange [IMP]
- response to amphetamine [IGI, IMP]
- response to ethanol [ISO]
- response to morphine [IMP]
- rhythmic process [ISO]
- sensory perception of pain [IMP]
- social behavior [IMP]
- startle response [IMP]
- suckling behavior [IMP]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- calcium channel activity [IDA, IGI, ISO]
- calcium ion binding [IDA]
- calmodulin binding [IDA]
- cation channel activity [IGI]
- enzyme binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- glycine binding [IMP, ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- calcium channel activity [IDA, IGI, ISO]
- calcium ion binding [IDA]
- calmodulin binding [IDA]
- cation channel activity [IGI]
- enzyme binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- glycine binding [IMP, ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- cell [IMP]
- cell surface [IDA]
- cytoplasm [IDA]
- dendrite [IDA, ISO]
- dendrite membrane [ISO]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- growth cone [NAS]
- integral component of plasma membrane [ISO]
- membrane [IC, IDA]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- synapse [IDA, ISO]
- synaptic cleft [ISO]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
PIK3R1
Gene Ontology Biological Process
- B cell differentiation [IMP]
- NFAT protein import into nucleus [IMP]
- cellular glucose homeostasis [IDA]
- cellular response to UV [IGI, IMP]
- cellular response to insulin stimulus [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- glucose metabolic process [ISO]
- growth hormone receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of blood pressure [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of heart rate [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of proteolysis [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- phosphatidylinositol phosphorylation [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO, TAS]
- positive regulation of RNA splicing [ISO]
- positive regulation of cell migration [IGI, ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of myoblast differentiation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of tumor necrosis factor production [IMP]
- protein phosphorylation [IDA]
- protein stabilization [ISO]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- response to cAMP [ISO]
- response to endoplasmic reticulum stress [IDA, ISO]
- response to glucocorticoid [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
N-methyl-d-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength via downstream signaling pathways. We report proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain. The NRC comprised 77 proteins organized into receptor, adaptor, signaling, cytoskeletal and novel proteins, of which 30 are implicated from binding studies and another 19 participate in NMDAR signaling. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID