BAIT
PTK2
FAK, FRNK, p125FAK
protein tyrosine kinase 2
GO Process (58)
GO Function (11)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [IMP]
- MAPK cascade [IMP]
- angiogenesis [IBA, ISO]
- blood vessel development [ISO]
- cellular chloride ion homeostasis [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system neuron axonogenesis [ISO]
- cytoskeleton organization [IBA]
- endothelial cell migration [ISO]
- ephrin receptor signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [ISO]
- extracellular matrix organization [ISO]
- fat cell differentiation [IEP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- microtubule cytoskeleton organization [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell migration [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [ISO]
- negative regulation of synapse assembly [ISO]
- neuron migration [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO, ISS]
- positive regulation of protein kinase B signaling [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of synaptic transmission [IMP]
- positive regulation of vasodilation [IMP]
- protein autophosphorylation [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO, ISS]
- regulation of cell proliferation [ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of osteoblast differentiation [ISO, ISS]
- response to arsenic-containing substance [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucose [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [IDA]
- cytoplasm [ISO]
- cytosol [ISO, ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO, TAS]
- intercalated disc [IDA]
- lamellipodium [ISO]
- nuclear body [IDA]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [IDA]
- stress fiber [ISO]
Rattus norvegicus
PREY
BCAR1
Cas, Crkas, P130CAS
breast cancer anti-estrogen resistance 1
GO Process (17)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO, ISS]
- G-protein coupled receptor signaling pathway [ISO, ISS]
- actin cytoskeleton organization [IMP]
- actin filament organization [ISO, ISS]
- antigen receptor-mediated signaling pathway [ISO, ISS]
- cell chemotaxis [ISO]
- cell migration [IMP, ISO, ISS]
- cellular response to hepatocyte growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [IDA]
- hepatocyte growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [IDA]
- integrin-mediated signaling pathway [ISO, ISS]
- neurotrophin TRK receptor signaling pathway [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO, ISS]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of endothelial cell migration [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs.
The focal adhesion kinase (FAK) and Crk-associated substrate, p130(Cas) (Cas), have been implicated in diverse signaling pathways including those mediated by integrins, G-protein-coupled receptors, tyrosine kinase receptors, and the v-src and v-crk oncogenes. The recent identification of a direct interaction between FAK and Cas prompted the examination of potential regulation of FAK.Cas complexes by factors that result in concomitant increase ... [more]
J. Biol. Chem. Feb. 28, 1997; 272(9);5501-9 [Pubmed: 9038154]
Throughput
- Low Throughput
Curated By
- BioGRID