Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.

Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, Wisden W, Triller A, Smart TG, Moss SJ

Controlling the number of functional gamma-aminobutyric acid A (GABA(A)) receptors in neuronal membranes is a crucial factor for the efficacy of inhibitory neurotransmission. Here we describe the direct interaction of GABA(A) receptors with the ubiquitin-like protein Plic-1. Furthermore, Plic-1 is enriched at inhibitory synapses and is associated with subsynaptic membranes. Functionally, Plic-1 facilitates GABA(A) receptor cell surface expression without affecting ... [more]

Nat. Neurosci. Sep. 01, 2001; 4(9);908-16 [Pubmed: 11528422]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

UBQLN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

kinase binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

GABRA2