CBL
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LCK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- T cell differentiation [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to peptide hormone stimulus [IBA]
- dephosphorylation [ISO]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of T cell receptor signaling pathway [IBA]
- positive regulation of gamma-delta T cell differentiation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- positive regulation of uterine smooth muscle contraction [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA, ISO]
- regulation of T cell receptor signaling pathway [IDA]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- release of sequestered calcium ion into cytosol [IDA]
- response to drug [ISO]
- response to hydrogen peroxide [ISO]
- response to mechanical stimulus [ISO]
- response to metal ion [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- ATPase binding [ISO]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- SH2 domain binding [ISO]
- antigen binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- ATPase binding [ISO]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- SH2 domain binding [ISO]
- antigen binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
Accumulating data show that the tyrosine protein kinase Zap-70 plays an essential role in T cell receptor-mediated signal transduction. However, the model of action, as well as the physiologically relevant substrates of Zap-70, have not been determined. We have attempted to identify a 120-kD tyrosine-phosphorylated protein (p120) that associates with Zap-70 in activated T lymphocytes. The results of our analyses ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBL LCK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| LCK CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID