TUBA1A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRM7
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA, ISO]
- adult behavior [ISO]
- associative learning [ISO]
- behavioral fear response [ISO]
- calcium ion transmembrane transport [ISO]
- conditioned taste aversion [ISO]
- learning or memory [TAS]
- memory [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- negative regulation of glutamate secretion [IDA]
- neurological system process [ISO]
- regulation of cyclase activity [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of sound [ISO]
- short-term memory [ISO]
- synaptic transmission [ISO]
- transmission of nerve impulse [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- asymmetric synapse [IDA]
- axon [IDA]
- axon terminus [IDA]
- cell cortex [ISO]
- cell surface [IDA]
- dendrite [IDA, ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- integral component of plasma membrane [IBA]
- membrane [IDA]
- neuronal cell body [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA, ISO]
- protein complex [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- synapse [IDA]
- terminal bouton [IDA]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interaction between metabotropic glutamate receptor 7 and alpha tubulin.
Metabotropic glutamate receptors (mGluRs) mediate a variety of responses to glutamate in the central nervous system. A primary role for group-III mGluRs is to inhibit neurotransmitter release from presynaptic terminals, but the molecular mechanisms that regulate presynaptic trafficking and activity of group-III mGluRs are not well understood. Here, we describe the interaction of mGluR7, a group-III mGluR and presynaptic autoreceptor, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRM7 TUBA1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| TUBA1A GRM7 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRM7 TUBA1A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID