CALM1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- activation of adenylate cyclase activity [IDA]
- calcium-mediated signaling [IMP]
- detection of calcium ion [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of cyclic nucleotide metabolic process [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cytokinesis [ISO]
- regulation of heart rate [ISO]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of store-operated calcium channel activity [IC]
- response to amphetamine [IEP]
- response to calcium ion [ISO]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
GRM7
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA, ISO]
- adult behavior [ISO]
- associative learning [ISO]
- behavioral fear response [ISO]
- calcium ion transmembrane transport [ISO]
- conditioned taste aversion [ISO]
- learning or memory [TAS]
- memory [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- negative regulation of glutamate secretion [IDA]
- neurological system process [ISO]
- regulation of cyclase activity [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of sound [ISO]
- short-term memory [ISO]
- synaptic transmission [ISO]
- transmission of nerve impulse [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- asymmetric synapse [IDA]
- axon [IDA]
- axon terminus [IDA]
- cell cortex [ISO]
- cell surface [IDA]
- dendrite [IDA, ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- integral component of plasma membrane [IBA]
- membrane [IDA]
- neuronal cell body [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA, ISO]
- protein complex [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- synapse [IDA]
- terminal bouton [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction between metabotropic glutamate receptor 7 and alpha tubulin.
Metabotropic glutamate receptors (mGluRs) mediate a variety of responses to glutamate in the central nervous system. A primary role for group-III mGluRs is to inhibit neurotransmitter release from presynaptic terminals, but the molecular mechanisms that regulate presynaptic trafficking and activity of group-III mGluRs are not well understood. Here, we describe the interaction of mGluR7, a group-III mGluR and presynaptic autoreceptor, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID