E2F4
Gene Ontology Biological Process
- blood circulation [IMP]
- cell volume homeostasis [IMP]
- cilium assembly [IMP]
- epithelial cell development [IMP]
- organ morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- regulation of cell cycle [TAS]
- regulation of cell proliferation [IDA]
- regulation of cell size [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IDA, IGI]
- regulation of transcription, DNA-templated [TAS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
RAB3GAP1
Gene Ontology Biological Process
- brain development [ISO]
- camera-type eye development [ISO]
- establishment of protein localization to endoplasmic reticulum membrane [ISO]
- face morphogenesis [ISO]
- hypothalamus development [ISO]
- lipid particle organization [ISO]
- positive regulation of GTP catabolic process [ISO]
- positive regulation of Rab GTPase activity [ISO]
- positive regulation of endoplasmic reticulum tubular network organization [ISO]
- regulation of GTPase activity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A dual role for A-type lamins in DNA double-strand break repair.
A-type lamins are emerging as regulators of nuclear organization and function. Changes in their expression are associated with cancer and mutations are linked to degenerative diseases -laminopathies-. Although a correlation exists between alterations in lamins and genomic instability, the molecular mechanisms remain largely unknown. We previously found that loss of A-type lamins leads to degradation of 53BP1 protein and defective ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID