CBLB
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TICAM1
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [IMP]
- apoptotic signaling pathway [IMP]
- defense response to virus [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- macrophage activation involved in immune response [IMP]
- positive regulation of B cell activation [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [IGI, IMP]
- positive regulation of chemokine biosynthetic process [IGI, IMP]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of natural killer cell activation [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of tumor necrosis factor production [IDA, IGI, IMP]
- positive regulation of type I interferon production [IMP]
- regulation of protein homodimerization activity [IMP]
- response to exogenous dsRNA [IDA, IMP, ISO]
- response to lipopolysaccharide [IGI, IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b.
Integrins are critical for the migration and function of leukocytes in inflammation. However, the interaction between integrin alpha(M) (CD11b), which has high expression in monocytes and macrophages, and Toll-like receptor (TLR)-triggered innate immunity remains unclear. Here we report that CD11b deficiency enhanced TLR-mediated responses in macrophages, rendering mice more susceptible to endotoxin shock and Escherichia coli-caused sepsis. CD11b was activated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID