BAIT
PER2
mKIAA0347, mPer2
period circadian clock 2
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
CSNK1D
1200006A05Rik, AA409348, D930010H05Rik, RP23-378G22.2
casein kinase 1, delta
GO Process (11)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [IMP]
- endocytosis [IBA]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [IMP]
- spindle assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A molecular mechanism for circadian clock negative feedback.
Circadian rhythms in mammals are generated by a feedback loop in which the three PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the CLOCK-BMAL1 dimer, which represses their own expression. Although fundamental, the mechanism of negative feedback in the mammalian clock, or any eukaryotic clock, is unknown. We analyzed protein constituents of PER complexes purified ... [more]
Science Jun. 17, 2011; 332(6036);1436-9 [Pubmed: 21680841]
Throughput
- Low Throughput
Additional Notes
- figure S1.
Curated By
- BioGRID