BAIT
XRCC5
KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
GO Process (10)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- DNA repair [TAS]
- double-strand break repair [TAS]
- double-strand break repair via nonhomologous end joining [IMP, TAS]
- establishment of integrated proviral latency [TAS]
- innate immune response [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of type I interferon production [TAS]
- telomere maintenance [TAS]
- viral process [TAS]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IMP]
- DNA binding [NAS]
- double-stranded DNA binding [TAS]
- double-stranded telomeric DNA binding [IDA]
- poly(A) RNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- telomeric DNA binding [IDA]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- 5'-deoxyribose-5-phosphate lyase activity [IMP]
- DNA binding [NAS]
- double-stranded DNA binding [TAS]
- double-stranded telomeric DNA binding [IDA]
- poly(A) RNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- telomeric DNA binding [IDA]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
DDX17
P72, RH70, RP3-434P1.1
DEAD (Asp-Glu-Ala-Asp) box helicase 17
GO Process (5)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential strategy to enhance cisplatin effectiveness. After cisplatin treatment, a balance between repair and apoptosis determines whether cancer cells proliferate or die. DNA-dependent protein kinase (DNA-PK) binds to DNA double ... [more]
Mol. Cancer Jun. 18, 2011; 10(0);74 [Pubmed: 21679440]
Throughput
- Low Throughput
Additional Notes
- table 1.
Curated By
- BioGRID