GIT5
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway [TAS]
- cAMP-mediated signaling [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of conjugation with cellular fusion [IMP]
- negative regulation of transcription by glucose [IMP]
- positive regulation of protein binding [IDA]
Gene Ontology Molecular Function
PYP1
Gene Ontology Biological Process
- inactivation of MAPK activity [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- negative regulation of transcription by glucose [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISS]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IMP]
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.
The Schizosaccharomyces pombe pyp1+ gene, encoding a protein tyrosine phosphatase (pyp1), was isolated as a high copy number suppressor of a mutation that results in reduced cAMP-dependent protein kinase (PKA) activity. Overexpression of pyp1+ inhibits both transcription of the fbp1 gene, which is negatively regulated by a glucose-induced activation of PKA, and sexual development, which is negatively regulated by PKA ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide accumulation (APO:0000149)
Additional Notes
- overexpression of pyp1 represses aberrant expression of the fbp1-ura4 reporter protein seen in PKA mutants
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PYP1 GIT5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -8.517 | BioGRID | 762232 |
Curated By
- BioGRID