SYK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [TAS]
- activation of JUN kinase activity [IMP]
- activation of MAPK activity [IDA, IMP]
- adaptive immune response [IBA]
- beta selection [IGI]
- blood vessel morphogenesis [IMP]
- cell migration [IBA]
- cell surface receptor signaling pathway [IDA, IMP]
- cellular response to molecule of fungal origin [IMP]
- defense response to bacterium [IMP]
- enzyme linked receptor protein signaling pathway [IDA]
- innate immune response [IMP]
- integrin-mediated signaling pathway [IMP]
- intracellular signal transduction [IDA, IMP]
- leukocyte activation involved in immune response [IMP]
- leukocyte cell-cell adhesion [ISO]
- leukotriene biosynthetic process [IMP]
- lymph vessel development [IMP]
- macrophage activation involved in immune response [IMP]
- neutrophil activation involved in immune response [IMP]
- neutrophil chemotaxis [ISO]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of alpha-beta T cell differentiation [IGI]
- positive regulation of alpha-beta T cell proliferation [IGI]
- positive regulation of bone resorption [IMP]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of cytokine secretion [IGI]
- positive regulation of gamma-delta T cell differentiation [IMP]
- positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process [IMP]
- positive regulation of interleukin-3 biosynthetic process [IMP]
- positive regulation of mast cell degranulation [IMP, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- protein autophosphorylation [IDA, ISO]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of arachidonic acid secretion [IMP]
- regulation of immune response [ISO]
- regulation of neutrophil degranulation [IMP]
- regulation of phagocytosis [IMP]
- regulation of platelet activation [IMP]
- regulation of platelet aggregation [IMP]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of superoxide anion generation [IMP]
- serotonin secretion [IMP]
- serotonin secretion by platelet [IMP]
- signal transduction by phosphorylation [IDA]
- transcription factor import into nucleus [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- ATP binding [IDA]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [IDA]
- ATP binding [IDA]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [IDA]
Gene Ontology Cellular Component
SLC4A1
Gene Ontology Biological Process
Gene Ontology Molecular Function- actin binding [ISO]
- anion:anion antiporter activity [ISO]
- ankyrin binding [ISO]
- bicarbonate transmembrane transporter activity [ISO]
- chloride transmembrane transporter activity [IDA]
- inorganic anion exchanger activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- actin binding [ISO]
- anion:anion antiporter activity [ISO]
- ankyrin binding [ISO]
- bicarbonate transmembrane transporter activity [ISO]
- chloride transmembrane transporter activity [IDA]
- inorganic anion exchanger activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases.
Syk and Zap-70 are related protein-tyrosine kinases implicated in antigen and Fc receptor signaling. While Zap-70 is restricted to T-cells and natural killer cells, Syk accumulates in B-cells, mast cells, platelets, and immature T-cells. In addition, we found that an isoform of Syk (SykB), which carries a 23-amino acid deletion in the "linker" region, is prominently expressed in bone marrow. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID