BAIT
SHARPIN
0610041B22Rik, AW121341, RBCKL1, SIPL1, cpdm
SHANK-associated RH domain interacting protein
GO Process (10)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- apoptotic nuclear changes [IMP]
- epidermis development [IMP]
- keratinization [IMP]
- mitochondrion organization [IMP]
- negative regulation of inflammatory response [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- protein homooligomerization [ISO]
- protein linear polyubiquitination [ISO]
- regulation of CD40 signaling pathway [ISO]
- regulation of tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ADCYAP1
PACAP
adenylate cyclase activating polypeptide 1
GO Process (36)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- ATP metabolic process [ISO]
- activation of adenylate cyclase activity [TAS]
- behavioral fear response [ISO]
- cAMP-mediated signaling [ISO]
- histamine secretion [ISO]
- intracellular signal transduction [IDA]
- negative regulation of Rho GTPase activity [ISO]
- negative regulation of acute inflammatory response to antigenic stimulus [ISO]
- negative regulation of acute inflammatory response to non-antigenic stimulus [ISO]
- negative regulation of cell cycle [IDA]
- negative regulation of glial cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [ISO]
- neuropeptide signaling pathway [ISO, TAS]
- ovarian follicle development [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of Rap GTPase activity [ISO]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA, ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of growth hormone secretion [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of somatostatin secretion [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasodilation [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of oligodendrocyte progenitor proliferation [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of protein localization [IDA, ISO]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SHARPIN negatively associates with TRAF2-mediated NFκB activation.
NFκB is an inducible transcriptional factor controlled by two principal signaling cascades and plays pivotal roles in diverse physiological processes including inflammation, apoptosis, oncogenesis, immunity, and development. Activation of NFκB signaling was detected in skin of SHAPRIN-deficient mice and can be diminished by an NFκB inhibitor. However, in vitro studies demonstrated that SHARPIN activates NFκB signaling by forming a linear ... [more]
PLoS ONE Aug. 11, 2011; 6(7);e21696 [Pubmed: 21829440]
Throughput
- Low Throughput
Curated By
- BioGRID