FOXP3
Gene Ontology Biological Process
- T cell activation [IDA]
- T cell homeostasis [NAS]
- chromatin remodeling [NAS]
- negative regulation of CREB transcription factor activity [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of T cell cytokine production [IDA]
- negative regulation of T cell proliferation [IDA]
- negative regulation of activated T cell proliferation [NAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cytokine biosynthetic process [IDA]
- negative regulation of cytokine secretion [IDA]
- negative regulation of histone deacetylation [IGI]
- negative regulation of immune response [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-10 production [IDA]
- negative regulation of interleukin-2 biosynthetic process [IMP]
- negative regulation of interleukin-2 production [IDA]
- negative regulation of interleukin-4 production [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of histone acetylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS]
- regulation of transcription, DNA-templated [NAS]
- response to virus [IEP]
Gene Ontology Molecular Function- NF-kappaB binding [NAS]
- NFAT protein binding [IPI]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- NF-kappaB binding [NAS]
- NFAT protein binding [IPI]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
HIST1H1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.
The forkhead box transcription factor FoxP3 controls the development and function of CD4+CD25+ regulatory T (Treg) cell. FoxP3 modulates gene expression in Treg cells by multiple epigenetic mechanisms that are not clearly defined. We identified FoxP3-interacting proteins in human T cells by co-immunoprecipitation/MS. We discovered that FoxP3 interacted with linker histone H1.5 via the leucine zipper (LZ) domain. Two independent ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 1b.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FOXP3 HIST1H1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 676712 | |
| HIST1H1B FOXP3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 676714 |
Curated By
- BioGRID