BAIT
PSMD10
AW554874, RP23-149O3.6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
GO Process (12)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- proteasome regulatory particle assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PSMC4
CIP21, MIP224
proteasome (prosome, macropain) 26S subunit, ATPase, 4
GO Process (1)
GO Function (0)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
Gankyrin is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome and enhances the degradation of the tumor suppressors pRb and p53. Here, we report the structure of gankyrin in complex with the C-terminal domain of S6 ATPase. Almost all of the seven ankyrin repeats of gankyrin ... [more]
Structure Feb. 01, 2007; 15(2);179-89 [Pubmed: 17292836]
Throughput
- Low Throughput
Curated By
- BioGRID