ZAP70
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- beta selection [IGI]
- cell migration [IBA]
- immune response [ISO]
- innate immune response [IBA]
- intracellular signal transduction [IMP]
- negative thymic T cell selection [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of T cell differentiation [IMP, ISO]
- positive regulation of alpha-beta T cell differentiation [IGI, IMP]
- positive regulation of alpha-beta T cell proliferation [IGI]
- positive regulation of calcium-mediated signaling [IMP]
- positive thymic T cell selection [IMP, ISO]
- protein autophosphorylation [IDA, IMP]
- protein phosphorylation [IDA, ISO]
- thymic T cell selection [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC4A1
Gene Ontology Biological Process
Gene Ontology Molecular Function- actin binding [ISO]
- anion:anion antiporter activity [ISO]
- ankyrin binding [ISO]
- bicarbonate transmembrane transporter activity [ISO]
- chloride transmembrane transporter activity [IDA]
- inorganic anion exchanger activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- actin binding [ISO]
- anion:anion antiporter activity [ISO]
- ankyrin binding [ISO]
- bicarbonate transmembrane transporter activity [ISO]
- chloride transmembrane transporter activity [IDA]
- inorganic anion exchanger activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.
Recent studies indicate that c-Cbl and its oncogenic variants can modulate the activity of protein tyrosine kinases. This finding is supported by studies showing that c-Cbl interacts directly with a negative regulatory tyrosine in ZAP-70, and that the levels of tyrosine-phosphorylated ZAP-70 and numerous other proteins are increased in TCR-stimulated thymocytes from c-Cbl-deficient mice. Here, we demonstrate that this enhanced ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ZAP70 SLC4A1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 676571 |
Curated By
- BioGRID