BAIT
NANOG
2410002E02Rik, ENK, ecat4
Nanog homeobox
GO Process (22)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cell proliferation [ISO]
- embryo development [IMP]
- endodermal cell fate specification [ISO]
- mesodermal cell fate commitment [IGI]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of cell differentiation [IDA]
- negative regulation of cell fate commitment [IDA, IGI]
- negative regulation of endodermal cell fate specification [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of mitotic cell cycle [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of cell differentiation [ISO]
- regulation of gene expression [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- somatic stem cell maintenance [ISO]
- stem cell differentiation [IDA, IMP]
- stem cell division [IDA]
- stem cell maintenance [IDA, IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription corepressor activity [IMP]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription corepressor activity [IMP]
- transcription regulatory region DNA binding [IDA]
Mus musculus
PREY
PRMT5
Jbp1, Skb1
protein arginine N-methyltransferase 5
GO Process (14)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- circadian regulation of gene expression [IMP]
- endothelial cell activation [ISO]
- histone H4-R3 methylation [IMP]
- histone arginine methylation [IBA]
- negative regulation of cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- peptidyl-arginine N-methylation [ISO]
- peptidyl-arginine methylation [ISO]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IBA, ISO]
- positive regulation of oligodendrocyte differentiation [ISO]
- protein methylation [ISO]
- regulation of DNA methylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- spliceosomal snRNP assembly [ISO]
Gene Ontology Molecular Function- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.
For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how transcriptional regulation is linked to chromosome organization in ESCs is not well understood. Here we show that the cohesin component RAD21 exhibits a functional role in maintaining ... [more]
PLoS ONE May. 19, 2011; 6(5);e19470 [Pubmed: 21589869]
Throughput
- High Throughput
Additional Notes
- table S5.
Curated By
- BioGRID