NANOG
Gene Ontology Biological Process
- cell proliferation [ISO]
- embryo development [IMP]
- endodermal cell fate specification [ISO]
- mesodermal cell fate commitment [IGI]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of cell differentiation [IDA]
- negative regulation of cell fate commitment [IDA, IGI]
- negative regulation of endodermal cell fate specification [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of mitotic cell cycle [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of cell differentiation [ISO]
- regulation of gene expression [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- somatic stem cell maintenance [ISO]
- stem cell differentiation [IDA, IMP]
- stem cell division [IDA]
- stem cell maintenance [IDA, IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription corepressor activity [IMP]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription corepressor activity [IMP]
- transcription regulatory region DNA binding [IDA]
DNAJA1
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [ISO]
- androgen receptor signaling pathway [IMP]
- negative regulation of JUN kinase activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of protein ubiquitination [ISO]
- positive regulation of apoptotic process [ISO]
- protein localization to mitochondrion [ISO]
- protein refolding [IBA]
- regulation of protein transport [ISO]
- sperm motility [IMP]
- spermatogenesis [IMP]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.
For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how transcriptional regulation is linked to chromosome organization in ESCs is not well understood. Here we show that the cohesin component RAD21 exhibits a functional role in maintaining ... [more]
Throughput
- High Throughput
Additional Notes
- table S5.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NANOG DNAJA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 458 | BioGRID | 885986 |
Curated By
- BioGRID