An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.

Kristensen JB, Nielsen AL, Jorgensen L, Kristensen LH, Helgstrand C, Juknaite L, Kristensen JL, Kastrup JS, Clausen RP, Olsen L, Gajhede M

To investigate ligand selectivity between the oncogenic KDM4C and tumor repressor protein KDM6A histone demethylases, KDM4C and KDM6A were enzymatically characterized, and subsequently, four compounds were tested for inhibitory effects. 2,4-dicarboxypyridine and (R)-N-oxalyl-O-benzyltyrosine (3) are both known to bind to a close KDM4C homolog and 3 binds in the part of the cavity that accommodates the side chain in position ... [more]

FEBS Lett. Jun. 23, 2011; 585(12);1951-6 [Pubmed: 21575637]

Throughput

Low Throughput

Additional Notes

synthetic peptide of substrates.

Curated By

BioGRID

Interaction Summary

KDM4C

Gene Ontology Biological Process

Gene Ontology Molecular Function

androgen receptor binding [IPI]enzyme binding [IPI]histone demethylase activity (H3-K9 specific) [IDA, IMP]

Gene Ontology Cellular Component

HIST2H3C