TBK1
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- defense response to Gram-positive bacterium [IMP]
- dendritic cell proliferation [IGI]
- negative regulation of gene expression [IMP]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interferon-beta production [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
IRF1
Gene Ontology Biological Process
- CD8-positive, alpha-beta T cell differentiation [IMP]
- I-kappaB kinase/NF-kappaB signaling [ISO]
- apoptotic process [ISO]
- cell cycle arrest [ISO]
- cellular response to interferon-beta [ISO]
- cellular response to interleukin-1 [ISO]
- cellular response to peptide hormone stimulus [ISO]
- cellular response to tumor necrosis factor [ISO]
- defense response to virus [IMP, ISO]
- interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of T-helper 2 cell differentiation [TAS]
- negative regulation of regulatory T cell differentiation [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of T-helper 1 cell differentiation [TAS]
- positive regulation of cell death [ISO]
- positive regulation of interferon-beta production [ISO]
- positive regulation of interleukin-12 biosynthetic process [IDA, IMP]
- positive regulation of natural killer cell differentiation [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- positive regulation of type I interferon production [IMP]
- regulation of CD8-positive, alpha-beta T cell proliferation [IMP]
- regulation of MyD88-dependent toll-like receptor signaling pathway [IMP]
- regulation of adaptive immune response [TAS]
- regulation of gene expression [IMP]
- regulation of innate immune response [TAS]
- response to growth hormone [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Intracellular detection of RNA virus infection is mediated by the RNA helicase RIG-I, which is recruited to mitochondria by the adaptor protein MAVS and triggers activation of the transcription factors NF-kappaB, IRF3 and IRF7. Here we demonstrate that virus-induced activation of IRF3 and IRF7 depended on the NF-kappaB modulator NEMO, which acted 'upstream' of the kinases TBK1 and IKKepsilon. IRF3 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID