BAIT
TNK2
tyrosine kinase, non-receptor, 2
GO Process (9)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [ISO, ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CDC42
cell division cycle 42
GO Process (59)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Golgi organization [IMP]
- actin cytoskeleton organization [ISO]
- actin filament branching [IMP]
- actin filament bundle assembly [ISO]
- actin filament organization [IMP]
- adherens junction organization [ISO]
- canonical Wnt signaling pathway [ISO]
- cardiac conduction system development [ISO]
- cellular protein localization [ISO]
- dendritic cell migration [ISO]
- epidermis morphogenesis [ISO]
- epithelial cell-cell adhesion [ISO]
- epithelial-mesenchymal cell signaling [ISO]
- establishment of Golgi localization [IMP]
- establishment of cell polarity [TAS]
- establishment or maintenance of apical/basal cell polarity [ISO]
- filopodium assembly [ISO]
- hair follicle morphogenesis [ISO]
- hair follicle placode formation [ISO]
- heart contraction [ISO]
- keratinization [ISO]
- keratinocyte development [ISO]
- multicellular organism growth [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron fate determination [ISO]
- nuclear migration [ISO]
- nucleus localization [ISO]
- organelle transport along microtubule [IMP]
- positive regulation of DNA replication [IMP]
- positive regulation of JNK cascade [IDA]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cytokinesis [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of hair follicle cell proliferation [ISO]
- positive regulation of intracellular protein transport [IMP]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of pseudopodium assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO, ISS]
- positive regulation of synapse structural plasticity [IMP]
- regulation of attachment of spindle microtubules to kinetochore [ISO, ISS]
- regulation of exocytosis [TAS]
- regulation of filopodium assembly [ISO, ISS]
- regulation of mitosis [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein kinase activity [ISO]
- regulation of protein metabolic process [ISO]
- regulation of protein stability [ISO]
- response to glucose [TAS]
- single organismal cell-cell adhesion [ISO]
- sprouting angiogenesis [IMP]
- submandibular salivary gland formation [IEP]
- substantia nigra development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- apical part of cell [ISO]
- cell [ISO]
- cell periphery [ISO]
- cell projection [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytosol [TAS]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- leading edge membrane [ISO]
- membrane [ISO, ISS]
- midbody [ISO, ISS]
- mitotic spindle [ISO, ISS]
- myelin sheath [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [IDA]
- spindle midzone [ISO, ISS]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation.
Based on the previous experiments with the N17 mutant of CDC42, it has been speculated, but not proved as yet, that CDC42 is required for Ras-induced malignant transformation of fibroblasts. However, since this inhibitor could sequester many GDP-dissociation stimulators (GDSs), such as DBL, OST and Tiam-1 which activate not only CDC42, but also Rho or Rac, in fact it is ... [more]
Oncogene Dec. 16, 1999; 18(54);7787-93 [Pubmed: 10618719]
Throughput
- Low Throughput
Curated By
- BioGRID