BAIT
CSF1R
AI323359, CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSF-R, M-CSFR
colony stimulating factor 1 receptor
GO Process (27)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [ISO]
- cell-cell junction maintenance [ISO]
- cellular response to cytokine stimulus [IMP]
- cellular response to macrophage colony-stimulating factor stimulus [IMP, ISO]
- cytokine-mediated signaling pathway [ISO]
- hemopoiesis [ISO]
- macrophage colony-stimulating factor signaling pathway [IMP]
- osteoclast differentiation [IMP]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell motility [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of chemokine secretion [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein serine/threonine kinase activity [IMP]
- positive regulation of protein tyrosine kinase activity [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- protein autophosphorylation [IDA, ISO]
- regulation of actin cytoskeleton reorganization [IMP]
- regulation of bone resorption [ISO]
- regulation of cell shape [IMP, ISO]
- ruffle organization [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
STAT3
1110034C02Rik, AW109958, Aprf, RP23-279L23.5
signal transducer and activator of transcription 3
GO Process (35)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages.
Colony-stimulating factor 1 (CSF-1) triggers the activation of intracellular proteins in macrophages through selective assembly of signalling complexes. The separation of multimeric complexes of the CSF-1 receptor (CSF-1R) by anion-exchange chromatography enabled the enrichment of low-stoichiometry complexes. A significant proportion of the receptor in CSF-1-stimulated cells that neither possessed detectable tyrosine kinase activity nor formed complexes was separated from the ... [more]
Mol. Cell. Biol. Jun. 01, 1999; 19(6);4079-92 [Pubmed: 10330148]
Throughput
- Low Throughput
Curated By
- BioGRID