BAIT
CSF1R
AI323359, CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSF-R, M-CSFR
colony stimulating factor 1 receptor
GO Process (27)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [ISO]
- cell-cell junction maintenance [ISO]
- cellular response to cytokine stimulus [IMP]
- cellular response to macrophage colony-stimulating factor stimulus [IMP, ISO]
- cytokine-mediated signaling pathway [ISO]
- hemopoiesis [ISO]
- macrophage colony-stimulating factor signaling pathway [IMP]
- osteoclast differentiation [IMP]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell motility [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of chemokine secretion [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein serine/threonine kinase activity [IMP]
- positive regulation of protein tyrosine kinase activity [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- protein autophosphorylation [IDA, ISO]
- regulation of actin cytoskeleton reorganization [IMP]
- regulation of bone resorption [ISO]
- regulation of cell shape [IMP, ISO]
- ruffle organization [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GRB2
AA408164, Ash, RP23-28I4.1
growth factor receptor bound protein 2
GO Process (15)
GO Function (14)
GO Component (14)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [ISO]
- anatomical structure formation involved in morphogenesis [IMP]
- branching involved in labyrinthine layer morphogenesis [IMP]
- cell differentiation [IMP]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [IDA]
- protein heterooligomerization [ISO]
- receptor internalization [ISO]
- regulation of MAPK cascade [IGI]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages.
Colony-stimulating factor 1 (CSF-1) triggers the activation of intracellular proteins in macrophages through selective assembly of signalling complexes. The separation of multimeric complexes of the CSF-1 receptor (CSF-1R) by anion-exchange chromatography enabled the enrichment of low-stoichiometry complexes. A significant proportion of the receptor in CSF-1-stimulated cells that neither possessed detectable tyrosine kinase activity nor formed complexes was separated from the ... [more]
Mol. Cell. Biol. Jun. 01, 1999; 19(6);4079-92 [Pubmed: 10330148]
Throughput
- Low Throughput
Curated By
- BioGRID