CBL
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LYN
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- B cell receptor signaling pathway [IDA]
- Fc receptor mediated inhibitory signaling pathway [IMP]
- Fc receptor mediated stimulatory signaling pathway [IMP]
- cellular response to DNA damage stimulus [IBA, ISO]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [ISO]
- central nervous system development [IBA]
- chemotaxis [IBA]
- cytokine secretion [ISO]
- dendritic cell differentiation [IMP]
- erythrocyte differentiation [IMP]
- hemoglobin biosynthetic process [TAS]
- hemopoiesis [IMP]
- histamine secretion by mast cell [ISO]
- immune response-regulating cell surface receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of B cell proliferation [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of intracellular signal transduction [IMP]
- negative regulation of mast cell proliferation [IMP]
- negative regulation of myeloid leukocyte differentiation [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of toll-like receptor 2 signaling pathway [IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IMP]
- neuron projection development [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- platelet degranulation [IMP]
- positive regulation of B cell receptor signaling pathway [IGI]
- positive regulation of Fc receptor mediated stimulatory signaling pathway [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [ISO]
- positive regulation of dendritic cell apoptotic process [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphorylation [ISO]
- positive regulation of stress-activated protein kinase signaling cascade [ISO]
- positive regulation of tyrosine phosphorylation of STAT protein [IMP]
- protein autophosphorylation [IDA, ISO, TAS]
- protein phosphorylation [ISO]
- regulation of B cell apoptotic process [IMP]
- regulation of B cell receptor signaling pathway [IMP]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cytokine production [IMP]
- regulation of cytokine secretion [IMP]
- regulation of erythrocyte differentiation [IMP]
- regulation of inflammatory response [IMP]
- regulation of mast cell activation [IMP]
- regulation of mast cell degranulation [IMP]
- regulation of monocyte chemotaxis [ISO]
- regulation of platelet aggregation [IMP]
- regulation of release of sequestered calcium ion into cytosol [IGI, ISO]
- response to hormone [IDA]
- signal transduction [TAS]
- tolerance induction to self antigen [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, ISO]
Gene Ontology Molecular Function- SH3 domain binding [IPI]
- enzyme binding [ISO]
- erythropoietin receptor binding [TAS]
- gamma-tubulin binding [ISO]
- glycosphingolipid binding [ISO]
- integrin binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI, ISO]
- protein kinase activity [IDA]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IBA, ISO]
- ubiquitin protein ligase binding [ISO]
- SH3 domain binding [IPI]
- enzyme binding [ISO]
- erythropoietin receptor binding [TAS]
- gamma-tubulin binding [ISO]
- glycosphingolipid binding [ISO]
- integrin binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI, ISO]
- protein kinase activity [IDA]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IBA, ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell [IMP]
- cell-cell adherens junction [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- integrin alpha2-beta1 complex [ISO]
- mast cell granule [ISO]
- membrane [ISO]
- membrane raft [ISO]
- mitochondrial crista [ISO]
- mitochondrial intermembrane space [ISO]
- mitochondrial membrane [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.
We have used mutant macrophages which are deficient in expression of Src-family kinases to define an integrin signaling pathway that is required for macrophage adhesion and migration. Following ligation of surface integrins by fibronectin, the p120(c-cbl) (Cbl) protein rapidly becomes tyrosine phosphorylated and associated with the Src-family kinases Fgr and Lyn. In hck-/-fgr-/-lyn-/- triple mutant cells, which are defective in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LYN CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 696838 | |
| LYN CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| LYN CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID