PCBP2
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mRNA metabolic process [NAS]
- mRNA splicing, via spliceosome [TAS]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IFIH1
Gene Ontology Biological Process
- cytoplasmic pattern recognition receptor signaling pathway in response to virus [TAS]
- detection of virus [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of interferon-alpha production [IMP, TAS]
- positive regulation of interferon-beta production [IMP, TAS]
- protein sumoylation [IDA]
- regulation of type III interferon production [TAS]
- response to virus [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
MAVS is critical in innate antiviral immunity as the sole adaptor for RIG-I-like helicases. MAVS regulation is essential for the prevention of excessive harmful immune responses. Here we identify PCBP2 as a negative regulator in MAVS-mediated signaling. Overexpression of PCBP2 abrogated cellular responses to viral infection, whereas knockdown of PCBP2 exerted the opposite effect. PCBP2 was induced after viral infection, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID