BAIT

UBLCP1

RGD1310386
ubiquitin-like domain containing CTD phosphatase 1
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Rattus norvegicus
PREY

RPN2

ribophorin II
GO Process (3)
GO Function (1)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.

Guo X, Engel JL, Xiao J, Tagliabracci VS, Wang X, Huang L, Dixon JE

Protein degradation by the 26S proteasome is a fundamental process involved in a broad range of cellular activities, yet how proteasome activity is regulated remains poorly understood. We report here that ubiquitin-like domain-containing C-terminal domain phosphatase 1 (UBLCP1) is a 26S proteasome phosphatase that regulates nuclear proteasome activity. UBLCP1 directly interacts with the proteasome via its UBL domain and is ... [more]

Proc. Natl. Acad. Sci. U.S.A. Nov. 15, 2011; 108(46);18649-54 [Pubmed: 21949367]

Throughput

  • Low Throughput

Curated By

  • BioGRID