BAIT

UBLCP1

RGD1310386
ubiquitin-like domain containing CTD phosphatase 1
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Rattus norvegicus
PREY

PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.

Guo X, Engel JL, Xiao J, Tagliabracci VS, Wang X, Huang L, Dixon JE

Protein degradation by the 26S proteasome is a fundamental process involved in a broad range of cellular activities, yet how proteasome activity is regulated remains poorly understood. We report here that ubiquitin-like domain-containing C-terminal domain phosphatase 1 (UBLCP1) is a 26S proteasome phosphatase that regulates nuclear proteasome activity. UBLCP1 directly interacts with the proteasome via its UBL domain and is ... [more]

Proc. Natl. Acad. Sci. U.S.A. Nov. 15, 2011; 108(46);18649-54 [Pubmed: 21949367]

Throughput

  • Low Throughput

Curated By

  • BioGRID