BAIT
LYN
p53Lyn, p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
GO Process (77)
GO Function (16)
GO Component (17)
Gene Ontology Biological Process
- B cell homeostasis [ISO, ISS]
- B cell receptor signaling pathway [ISO]
- Fc receptor mediated inhibitory signaling pathway [ISO, ISS]
- Fc receptor mediated stimulatory signaling pathway [ISO, ISS]
- cell migration [IBA]
- cellular response to DNA damage stimulus [IBA, ISO]
- cellular response to extracellular stimulus [IEP]
- cellular response to heat [IEP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [ISO]
- chemotaxis [IBA]
- cytokine secretion [IMP]
- dendritic cell differentiation [IBA, ISO, ISS]
- erythrocyte differentiation [ISO, ISS]
- hemopoiesis [ISO]
- histamine secretion by mast cell [IMP]
- immune response-regulating cell surface receptor signaling pathway [ISO, ISS]
- innate immune response [IBA]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- negative regulation of B cell proliferation [IBA, ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of intracellular signal transduction [ISO, ISS]
- negative regulation of mast cell proliferation [IBA, ISO, ISS]
- negative regulation of myeloid leukocyte differentiation [ISO]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISO, ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISO, ISS]
- neuron projection development [IBA, ISO]
- oligodendrocyte development [IEP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet degranulation [IBA, ISO, ISS]
- positive regulation of B cell receptor signaling pathway [ISO]
- positive regulation of Fc receptor mediated stimulatory signaling pathway [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of cellular component movement [ISO]
- positive regulation of dendritic cell apoptotic process [IBA, ISO, ISS]
- positive regulation of glial cell proliferation [IDA]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [ISO]
- positive regulation of tyrosine phosphorylation of STAT protein [ISO, ISS]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of B cell apoptotic process [IBA, ISO]
- regulation of B cell receptor signaling pathway [IBA, ISO, ISS]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cytokine production [ISO, ISS]
- regulation of cytokine secretion [ISO]
- regulation of erythrocyte differentiation [ISO, ISS]
- regulation of inflammatory response [ISO]
- regulation of mast cell activation [ISO, ISS]
- regulation of mast cell degranulation [IBA, ISO, ISS]
- regulation of monocyte chemotaxis [ISO]
- regulation of platelet aggregation [IBA, ISO, ISS]
- regulation of release of sequestered calcium ion into cytosol [IMP, ISO]
- response to amino acid [IEP]
- response to axon injury [IEP]
- response to carbohydrate [IEP]
- response to drug [IEP]
- response to hormone [ISO, ISS]
- response to insulin [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to sterol depletion [IEP]
- response to toxic substance [IEP]
- tolerance induction to self antigen [IBA, ISO, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell [ISO]
- cell-cell adherens junction [IDA]
- cytoplasm [ISO, ISS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- integrin alpha2-beta1 complex [IDA]
- mast cell granule [IMP]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrial crista [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial membrane [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
PREY
LYN
p53Lyn, p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
GO Process (77)
GO Function (16)
GO Component (17)
Gene Ontology Biological Process
- B cell homeostasis [ISO, ISS]
- B cell receptor signaling pathway [ISO]
- Fc receptor mediated inhibitory signaling pathway [ISO, ISS]
- Fc receptor mediated stimulatory signaling pathway [ISO, ISS]
- cell migration [IBA]
- cellular response to DNA damage stimulus [IBA, ISO]
- cellular response to extracellular stimulus [IEP]
- cellular response to heat [IEP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [ISO]
- chemotaxis [IBA]
- cytokine secretion [IMP]
- dendritic cell differentiation [IBA, ISO, ISS]
- erythrocyte differentiation [ISO, ISS]
- hemopoiesis [ISO]
- histamine secretion by mast cell [IMP]
- immune response-regulating cell surface receptor signaling pathway [ISO, ISS]
- innate immune response [IBA]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- negative regulation of B cell proliferation [IBA, ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of intracellular signal transduction [ISO, ISS]
- negative regulation of mast cell proliferation [IBA, ISO, ISS]
- negative regulation of myeloid leukocyte differentiation [ISO]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISO, ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISO, ISS]
- neuron projection development [IBA, ISO]
- oligodendrocyte development [IEP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet degranulation [IBA, ISO, ISS]
- positive regulation of B cell receptor signaling pathway [ISO]
- positive regulation of Fc receptor mediated stimulatory signaling pathway [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of cellular component movement [ISO]
- positive regulation of dendritic cell apoptotic process [IBA, ISO, ISS]
- positive regulation of glial cell proliferation [IDA]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [ISO]
- positive regulation of tyrosine phosphorylation of STAT protein [ISO, ISS]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of B cell apoptotic process [IBA, ISO]
- regulation of B cell receptor signaling pathway [IBA, ISO, ISS]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cytokine production [ISO, ISS]
- regulation of cytokine secretion [ISO]
- regulation of erythrocyte differentiation [ISO, ISS]
- regulation of inflammatory response [ISO]
- regulation of mast cell activation [ISO, ISS]
- regulation of mast cell degranulation [IBA, ISO, ISS]
- regulation of monocyte chemotaxis [ISO]
- regulation of platelet aggregation [IBA, ISO, ISS]
- regulation of release of sequestered calcium ion into cytosol [IMP, ISO]
- response to amino acid [IEP]
- response to axon injury [IEP]
- response to carbohydrate [IEP]
- response to drug [IEP]
- response to hormone [ISO, ISS]
- response to insulin [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to sterol depletion [IEP]
- response to toxic substance [IEP]
- tolerance induction to self antigen [IBA, ISO, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell [ISO]
- cell-cell adherens junction [IDA]
- cytoplasm [ISO, ISS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- integrin alpha2-beta1 complex [IDA]
- mast cell granule [IMP]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrial crista [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial membrane [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b.
Aggregation of the high-affinity immunoglobulin E (IgE) receptor (FcepsilonRI) on mast cells induces a number of biochemical events, including protein-tyrosine phosphorylation leading to degranulation and multiple cytokine gene transcription. Here, we have demonstrated that a second member of the Cbl family of ubiquitin-protein ligase Cbl-b translocates into the lipid raft after FcepsilonRI engagement. Overexpression of Cbl-b in the lipid raft ... [more]
Blood Mar. 01, 2004; 103(5);1779-86 [Pubmed: 14604964]
Throughput
- Low Throughput
Additional Notes
- figure 5B.
Curated By
- BioGRID