GAB2
Gene Ontology Biological Process
- cell migration [ISO]
- integrin-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- osteoclast differentiation [ISO, ISS]
- phosphatidylinositol-mediated signaling [ISO, ISS]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of mast cell degranulation [ISO, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBB
Gene Ontology Biological Process
- adipose tissue development [ISO]
- energy homeostasis [ISO]
- fat pad development [ISO]
- female gonad development [ISO]
- female meiosis I [ISO]
- hypothalamus gonadotrophin-releasing hormone neuron development [ISO]
- male gonad development [ISO]
- male meiosis I [ISO]
- mitochondrion transport along microtubule [ISO]
- neuron projection morphogenesis [ISO]
- positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- regulation of mitochondrial membrane potential [ISO]
- regulation of neuron death [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- seminiferous tubule development [ISO]
- ubiquitin homeostasis [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b.
Aggregation of the high-affinity immunoglobulin E (IgE) receptor (FcepsilonRI) on mast cells induces a number of biochemical events, including protein-tyrosine phosphorylation leading to degranulation and multiple cytokine gene transcription. Here, we have demonstrated that a second member of the Cbl family of ubiquitin-protein ligase Cbl-b translocates into the lipid raft after FcepsilonRI engagement. Overexpression of Cbl-b in the lipid raft ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6B.
Curated By
- BioGRID