UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STAT1
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- apoptotic process [ISS]
- blood circulation [ISS]
- cellular response to interferon-beta [IMP]
- cytokine-mediated signaling pathway [TAS]
- endothelial cell migration [IMP]
- interferon-gamma-mediated signaling pathway [IDA, ISS, TAS]
- metanephric mesenchymal cell differentiation [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- negative regulation by virus of viral protein levels in host cell [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISS]
- negative regulation of metanephric nephron tubule epithelial cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of smooth muscle cell proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of apoptotic process [TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- renal tubule development [IMP]
- response to cAMP [ISS]
- response to cytokine [ISS]
- response to peptide hormone [ISS]
- transcription from RNA polymerase II promoter [IDA]
- tumor necrosis factor-mediated signaling pathway [IDA]
- type I interferon signaling pathway [ISS, TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
A conserved catalytic residue in the ubiquitin-conjugating enzyme family.
Ubiquitin (Ub) regulates diverse functions in eukaryotes through its attachment to other proteins. The defining step in this protein modification pathway is the attack of a substrate lysine residue on Ub bound through its C-terminus to the active site cysteine residue of a Ub-conjugating enzyme (E2) or certain Ub ligases (E3s). So far, these E2 and E3 cysteine residues are ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID