MTUS1
Gene Ontology Cellular Component
PTPN6
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- abortive mitotic cell cycle [ISO]
- cell differentiation [ISO, ISS]
- cell proliferation [ISO, ISS]
- hematopoietic progenitor cell differentiation [ISO]
- intracellular signal transduction [ISO]
- megakaryocyte development [ISO]
- natural killer cell mediated cytotoxicity [ISO]
- negative regulation of B cell receptor signaling pathway [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of T cell proliferation [ISO]
- negative regulation of T cell receptor signaling pathway [ISO]
- negative regulation of humoral immune response mediated by circulating immunoglobulin [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- peptidyl-tyrosine dephosphorylation [ISO, ISS, TAS]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet aggregation [ISO]
- platelet formation [ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- protein dephosphorylation [ISO, ISS, TAS]
- regulation of B cell differentiation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of release of sequestered calcium ion into cytosol [ISO]
- response to wounding [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1.
Angiotensin II (Ang II) type 2 (AT2) receptors are abundantly expressed not only in the fetal brain where they probably contribute to brain development, but also in pathological conditions to protect the brain against stroke; however, the detailed mechanisms are unclear. Here, we demonstrated that AT2 receptor signaling induced neural differentiation via an increase in MMS2, one of the ubiquitin-conjugating ... [more]
Throughput
- Low Throughput
Additional Notes
- ATIP from rat neurons
Curated By
- BioGRID