TGFBR1
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- aging [IEP]
- angiogenesis [ISO]
- anterior/posterior pattern specification [ISO]
- artery morphogenesis [ISO]
- blastocyst development [ISO]
- cell motility [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- collagen fibril organization [ISO]
- digestive tract development [IEP]
- embryo development [IEP]
- embryo implantation [IEP]
- embryonic cranial skeleton morphogenesis [ISO]
- endothelial cell migration [ISO]
- epithelial to mesenchymal transition [ISO]
- germ cell migration [ISO]
- heart development [ISO]
- in utero embryonic development [ISO]
- kidney development [ISO]
- lens development in camera-type eye [ISO]
- lung development [IEP]
- male gonad development [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of chondrocyte differentiation [ISO]
- negative regulation of endothelial cell differentiation [IMP]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- neuron fate commitment [ISO]
- organ regeneration [IEP]
- palate development [ISO]
- parathyroid gland development [ISO]
- pathway-restricted SMAD protein phosphorylation [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- pharyngeal system development [ISO]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of filopodium assembly [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-embryonic development [ISO]
- protein autophosphorylation [IMP]
- protein phosphorylation [IMP, ISO]
- regulation of gene expression [ISO]
- regulation of protein binding [ISO]
- regulation of protein ubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to cholesterol [ISO]
- response to electrical stimulus [IEP]
- response to estrogen [IDA]
- response to hypoxia [IEP]
- response to organic cyclic compound [IEP]
- response to prostaglandin E [IEP]
- response to toxic substance [IEP]
- signal transduction [ISO]
- skeletal system development [ISO]
- skeletal system morphogenesis [ISO]
- thymus development [ISO]
- transforming growth factor beta receptor signaling pathway [IMP, ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
Gene Ontology Molecular Function- ATP binding [IMP, ISO]
- I-SMAD binding [ISO]
- SMAD binding [ISO]
- growth factor binding [ISO]
- protein complex binding [IPI]
- protein heterodimerization activity [IMP]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [IMP, ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor activity, type I [IMP, ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [IPI]
- ATP binding [IMP, ISO]
- I-SMAD binding [ISO]
- SMAD binding [ISO]
- growth factor binding [ISO]
- protein complex binding [IPI]
- protein heterodimerization activity [IMP]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [IMP, ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor activity, type I [IMP, ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
SMURF2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis.
Upregulation of transforming growth factor beta (TGF-beta)/Smad signaling has been implicated in the primary pathogenesis of renal fibrosis. The ubiquitin-proteasome pathway has an important influence on TGF-beta signaling through regulating Smad degradation. As E3 ubiquitin ligases, both Arkadia and Smurf2 are involved in this prosess. In this study, we focused on Arkadia, Smurf2, Smad7, and TGF-beta type I receptor (TbetaRI), ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TGFBR1 SMURF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID