GRIA1
Gene Ontology Biological Process
- cellular response to amine stimulus [IEP]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to peptide hormone stimulus [IEP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- long term synaptic depression [ISO]
- long-term memory [IMP, ISO]
- neuronal action potential [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of synaptic transmission [IMP]
- receptor internalization [IDA, ISO]
- regulation of receptor recycling [IMP]
- regulation of synaptic plasticity [IMP, NAS]
- regulation of synaptic transmission [IDA]
- response to arsenic-containing substance [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to estradiol [IEP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to toxic substance [IMP]
- spinal cord development [IEP]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [NAS]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- axonal spine [ISO]
- cell surface [IDA, ISO]
- cytosol [IDA]
- dendrite [ISO, ISS]
- dendrite membrane [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [IDA]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [ISO, TAS]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- protein complex [IDA]
- recycling endosome [ISO]
- synapse [IDA, IMP, ISO]
- synaptic vesicle [ISO]
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex.
Chronic stress could trigger maladaptive changes associated with stress-related mental disorders; however, the underlying mechanisms remain elusive. In this study, we found that exposing juvenile male rats to repeated stress significantly impaired the temporal order recognition memory, a cognitive process controlled by the prefrontal cortex (PFC). Concomitantly, significantly reduced AMPAR- and NMDAR-mediated synaptic transmission and glutamate receptor expression were found ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID