GRIN1
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- associative learning [ISO]
- calcium ion homeostasis [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to manganese ion [IEP]
- cerebral cortex development [ISO]
- conditioned taste aversion [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO, TAS]
- long-term memory [ISO]
- male mating behavior [ISO]
- memory [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular process [ISO]
- olfactory learning [ISO]
- pons maturation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- prepulse inhibition [ISO]
- propylene metabolic process [ISO]
- protein tetramerization [IDA]
- regulation of axonogenesis [ISO]
- regulation of cell communication [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of respiratory gaseous exchange [ISO]
- regulation of synapse assembly [ISO]
- regulation of synaptic plasticity [ISO]
- respiratory gaseous exchange [ISO]
- response to amine [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to ethanol [ISO]
- response to fungicide [IEP]
- response to morphine [ISO]
- response to organic cyclic compound [IEP]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission, glutamatergic [IBA, ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO, TAS]
- cell [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- dendrite membrane [IDA]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex.
Chronic stress could trigger maladaptive changes associated with stress-related mental disorders; however, the underlying mechanisms remain elusive. In this study, we found that exposing juvenile male rats to repeated stress significantly impaired the temporal order recognition memory, a cognitive process controlled by the prefrontal cortex (PFC). Concomitantly, significantly reduced AMPAR- and NMDAR-mediated synaptic transmission and glutamate receptor expression were found ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBC GRIN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID