BAIT

RPS6KA1

HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, RP11-492M19.2
ribosomal protein S6 kinase, 90kDa, polypeptide 1
GO Process (26)
GO Function (4)
GO Component (4)

Gene Ontology Cellular Component

Homo sapiens
PREY

PDCD4

H731, RP11-348N5.4
programmed cell death 4 (neoplastic transformation inhibitor)
GO Process (5)
GO Function (1)
GO Component (4)
Homo sapiens

Biochemical Activity (Phosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Regulatory Effects of Programmed Cell Death 4 (PDCD4) Protein in Interferon (IFN)-Stimulated Gene Expression and Generation of Type I IFN Responses.

Kroczynska B, Sharma B, Eklund EA, Fish EN, Platanias LC

The precise mechanisms by which the activation of interferon (IFN) receptors (IFNRs) ultimately controls mRNA translation of specific target genes to induce IFN-dependent biological responses remain ill defined. We provide evidence that IFN-α induces phosphorylation of programmed cell death 4 (PDCD4) protein on Ser67. This IFN-α-dependent phosphorylation is mediated by either the p70 S6 kinase (S6K) or the p90 ribosomal ... [more]

Mol. Cell. Biol. Jul. 01, 2012; 32(14);2809-22 [Pubmed: 22586265]

Throughput

  • Low Throughput

Additional Notes

  • figure 3B.

Curated By

  • BioGRID