BAIT
CLDN2
RP1-75H8.2
claudin 2
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TJP2
C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, RP11-16N10.1
tight junction protein 2
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
SUMOylation of claudin-2.
The C-terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two-hybrid screen with the tail of human claudin-2 against a human kidney cDNA library and identified interactions with the PDZ3 domain of ZO-2 as well as ubiquitin-conjugating enzyme E2I (SUMO ligase-1) and E3 SUMO-protein ligase PIAS; the first is ... [more]
Ann. N. Y. Acad. Sci. Jul. 01, 2012; 1258(1);60-4 [Pubmed: 22731716]
Throughput
- High Throughput
Curated By
- BioGRID