MAP1LC3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATG4B
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IBA, ISO]
- autophagy [ISO, ISS]
- cellular response to nitrogen starvation [IBA]
- mitochondrion degradation [IBA]
- nucleophagy [IBA]
- positive regulation of autophagy [ISO]
- positive regulation of protein catabolic process [ISO]
- protein delipidation [IBA]
- protein processing [IBA]
- protein targeting to membrane [IBA]
- proteolysis [ISO, ISS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions and leads to liver injury and neurodegeneration, but the details of abnormalities related to impaired autophagy are largely unknown. Here we used mouse genetic analyses to define the roles of autophagy in the aforementioned events. We report that the ubiquitin- and LC3-binding protein "p62" regulates the formation of protein ... [more]
Throughput
- Low Throughput
Additional Notes
- table S1.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ATG4B MAP1LC3A | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.832 | BioGRID | 2682166 |
Curated By
- BioGRID