BAIT
TFAP2C
AP2-GAMMA, ERF1, TFAP2G, hAP-2g, RP4-539E24.1
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
GO Process (7)
GO Function (8)
GO Component (1)
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- male gonad development [IEP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell proliferation [IBA]
- regulation of gene expression, epigenetic [IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- core promoter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- core promoter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
Homo sapiens
PREY
UBE2I
C358B7.1, P18, UBC9, LA16c-358B7.1
ubiquitin-conjugating enzyme E2I
GO Process (8)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
The members of the AP-2 family of transcription factors are developmentally regulated and have distinct yet overlapping functions in the regulation of many genes governing growth and differentiation. All AP-2 factors appear to be capable of binding very similar DNA recognition sites, and the determinants of functional specificity remain to be elucidated. AP-2 transcription factors have been shown to act ... [more]
J. Biol. Chem. Aug. 23, 2002; 277(34);30798-804 [Pubmed: 12072434]
Throughput
- High Throughput|Low Throughput
Curated By
- BioGRID