BAIT
TFAP2B
AP-2B, AP2-B, RP4-753D5.1
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
GO Process (35)
GO Function (16)
GO Component (1)
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- calcium ion homeostasis [ISS]
- cellular ammonia homeostasis [ISS]
- cellular creatinine homeostasis [ISS]
- cellular urea homeostasis [ISS]
- collecting duct development [ISS]
- distal tubule development [ISS]
- ductus arteriosus closure [ISS]
- fat cell differentiation [IEP]
- forelimb morphogenesis [ISS]
- glucose homeostasis [ISS]
- glucose metabolic process [IMP]
- hindlimb morphogenesis [ISS]
- kidney development [ISS]
- magnesium ion homeostasis [ISS]
- negative regulation of apoptotic process [IDA, ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- phosphate ion homeostasis [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of urine volume [ISS]
- potassium ion homeostasis [ISS]
- regulation of BMP signaling pathway [ISS]
- regulation of cell differentiation [IDA]
- regulation of insulin secretion [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal water homeostasis [ISS]
- retina layer formation [IEP]
- sodium ion homeostasis [ISS]
- sympathetic nervous system development [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription coactivator activity [ISS]
- RNA polymerase II transcription corepressor activity [ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- DNA binding [TAS]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription coactivator activity [ISS]
- RNA polymerase II transcription corepressor activity [ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
Homo sapiens
PREY
UBE2I
C358B7.1, P18, UBC9, LA16c-358B7.1
ubiquitin-conjugating enzyme E2I
GO Process (8)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
The members of the AP-2 family of transcription factors are developmentally regulated and have distinct yet overlapping functions in the regulation of many genes governing growth and differentiation. All AP-2 factors appear to be capable of binding very similar DNA recognition sites, and the determinants of functional specificity remain to be elucidated. AP-2 transcription factors have been shown to act ... [more]
J. Biol. Chem. Aug. 23, 2002; 277(34);30798-804 [Pubmed: 12072434]
Throughput
- Low Throughput
Curated By
- BioGRID