CHKA
Gene Ontology Biological Process
- CDP-choline pathway [IDA, TAS]
- glycerophospholipid biosynthetic process [TAS]
- lipid metabolic process [TAS]
- lipid transport [TAS]
- phosphatidylcholine biosynthetic process [IDA, TAS]
- phosphatidylethanolamine biosynthetic process [IDA, TAS]
- phospholipid metabolic process [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
SKP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Deregulated Skp2 function promotes cell transformation, and this is consistent with observations of Skp2 overexpression in many human cancers. However, the mechanisms underlying elevated Skp2 expression are still unknown. Here we show that the serine/threonine protein kinase Akt1, but not Akt2, directly controls Skp2 stability by a mechanism that involves degradation by the APC-Cdh1 ubiquitin ligase complex. We show further ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 5. Phosphorylation of Skp2 at Ser72 triggers the subsequent phosphorylation of the Ser75 site by Casein Kinase I
Curated By
- BioGRID