VHL
Gene Ontology Biological Process
- cell morphogenesis [NAS]
- cellular response to hypoxia [TAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- positive regulation of cell differentiation [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- protein stabilization [NAS]
- protein ubiquitination [IDA, IMP]
- proteolysis [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
OSR1
Gene Ontology Biological Process
- cell differentiation [ISS]
- cell proliferation involved in kidney development [ISS]
- chondrocyte differentiation [ISS]
- embryonic digit morphogenesis [ISS]
- embryonic forelimb morphogenesis [ISS]
- embryonic hindlimb morphogenesis [ISS]
- embryonic skeletal joint development [ISS]
- embryonic skeletal joint morphogenesis [ISS]
- embryonic skeletal limb joint morphogenesis [ISS]
- heart development [ISS]
- mesangial cell development [ISS]
- mesonephric duct morphogenesis [ISS]
- mesonephros development [ISS]
- metanephric cap mesenchymal cell proliferation involved in metanephros development [ISS]
- metanephric epithelium development [ISS]
- metanephric glomerulus vasculature development [ISS]
- metanephric interstitial fibroblast development [ISS]
- metanephric mesenchymal cell differentiation [ISS]
- metanephric mesenchyme development [ISS]
- metanephric mesenchyme morphogenesis [ISS]
- metanephric nephron tubule development [ISS]
- metanephric smooth muscle tissue development [ISS]
- middle ear morphogenesis [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of epithelial cell differentiation [ISS]
- negative regulation of nephron tubule epithelial cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- odontogenesis [ISS]
- palate development [ISS]
- pattern specification involved in metanephros development [ISS]
- positive regulation of bone mineralization [ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of gastrulation [IMP]
- positive regulation of gene expression [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- posterior mesonephric tubule development [ISS]
- pronephros development [IMP]
- renal vesicle progenitor cell differentiation [ISS]
- specification of anterior mesonephric tubule identity [ISS]
- specification of posterior mesonephric tubule identity [ISS]
- stem cell differentiation [ISS]
- ureter urothelium development [ISS]
- ureteric bud development [ISS]
- urogenital system development [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway.
Oxygen homeostasis is crucial for a myriad of developmental, physiological, and pathophysiological processes. Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a pivotal role in response to hypoxia by transcriptionally activating target genes involving oxygen uptake, transport, delivery, and consumption. HIF-1alpha activity is regulated primarily through the ubiquitin-proteasome degradation pathway, which targets the oxygen-dependent degradation domain (ODD) of HIF-1alpha. In particular, the von ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OSR1 VHL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| OSR1 VHL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID