BAIT
ZP3
ZP3A, ZP3B, ZPC, Zp-3
zona pellucida glycoprotein 3 (sperm receptor)
GO Process (32)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- binding of sperm to zona pellucida [IDA, IGI, IMP, TAS]
- blastocyst formation [ISS]
- calcium ion transmembrane transport [IDA]
- egg coat formation [ISS]
- humoral immune response mediated by circulating immunoglobulin [ISS]
- intracellular protein transport [ISS]
- intracellular signal transduction [IMP]
- manganese ion transmembrane transport [ISS]
- manganese ion transport [ISS]
- multicellular organism reproduction [TAS]
- negative regulation of binding of sperm to zona pellucida [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- oocyte development [ISS]
- phosphatidylinositol-mediated signaling [ISS]
- positive regulation of T cell proliferation [ISS]
- positive regulation of acrosomal vesicle exocytosis [IDA, IMP]
- positive regulation of acrosome reaction [IDA]
- positive regulation of antral ovarian follicle growth [ISS]
- positive regulation of calcium ion import [IDA]
- positive regulation of humoral immune response [IDA]
- positive regulation of inflammatory response [ISS]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-4 production [ISS]
- positive regulation of leukocyte migration [ISS]
- positive regulation of ovarian follicle development [ISS]
- positive regulation of phosphatidylinositol biosynthetic process [ISS]
- positive regulation of protein kinase B signaling [ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of type IV hypersensitivity [ISS]
- protein kinase C signaling [IMP]
- single fertilization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBAP2L
NICE-4, RP11-205M9.4
ubiquitin associated protein 2-like
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system.
Sperm proteins that interact with zona pellucida 3 (ZP3) have not been clearly identified in humans. In the present study, the yeast two-hybrid (Y2H) system was used to identify human sperm proteins that interact with human ZP3. Human ZP3 cDNA was cloned into pAS2-1 yeast vector and used as bait to find reactive proteins in the human testis cDNA library. ... [more]
J. Reprod. Immunol. Jan. 01, 2010; 84(1);24-31 [Pubmed: 19945174]
Throughput
- High Throughput|Low Throughput
Additional Notes
- mammalian two-hybrid system.
- table 2.
Curated By
- BioGRID